oxprenolol hydrochloride

CLINICAL USE

Beta-1 adrenoceptor blocker:Hypertension Angina Arrhythmias Anxiety

DOSE IN NORMAL RENAL FUNCTION

Hypertension, angina: 80–160 mg daily in 2–3 divided doses; maximum 320 mg dailyArrhythmias: 40–240 mg daily in 2–3 divided dosesAnxiety: 40–80 mg daily in 1–2 divided doses

PHARMACOKINETICS

Molecular weight :301.8

%Protein binding :70–80

%Excreted unchanged in urine : <3

Volume of distribution (L/kg) :1.2

half-life – normal/ESRD (hrs) :1–2/unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unlikely dialysability. Dose as in normal renal function.

HD :Unlikely dialysability. Dose as in normal renal function.

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anaesthetics: enhanced hypotensive effect

Analgesics: NSAIDs antagonise hypotensive effect

Anti-arrhythmics: increased risk of myocardial depression and bradycardia; increased risk of bradycardia, myocardial depression and AV block with amiodarone

Antidepressants: enhanced hypotensive effect with MAOIsAntihypertensives: enhanced hypotensive effect; increased risk of first dose hypotensive effect with post-synaptic alpha-blockers such as prazosin; increased risk of withdrawal hypertension with clonidine; increased risk of bradycardia and AV block with diltiazem; severe hypotension and heart failure occasionally with nifedipine; asystole, severe hypotension and heart failure with verapamil

Antimalarials: increased risk of bradycardia with mefloquine

Antipsychotics: enhanced hypotensive effect with phenothiazines

Diuretics: enhanced hypotensive effect

Moxisylyte: possibly severe postural hypotensionSevere hypertension with adrenaline and noradrenaline (especially with non-selective beta-blockers) and possibly with dopamineTropisetron: increased risk of ventricular arrhythmias – use with caution

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

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Comments

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OTHER INFORMATION

Use with caution in patients with chronic obstructive airways disease, asthma or diabetesRhabdomyolysis with myoglobinuria has been reported in severe overdosage with oxprenolol

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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